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Tuesday, May 12, 2020 | History

1 edition of Therapeutic applications of quadruplex nucleic acids found in the catalog.

Therapeutic applications of quadruplex nucleic acids

Stephen Neidle

Therapeutic applications of quadruplex nucleic acids

by Stephen Neidle

  • 315 Want to read
  • 35 Currently reading

Published by Elsevier/Academic Press in London, Waltham, MA .
Written in English

    Subjects:
  • G-Quadruplexes,
  • Pharmacology,
  • Quadruplex nucleic acids,
  • Neoplasms,
  • Telomere,
  • Drug therapy,
  • Therapeutic use,
  • Chemistry,
  • Antineoplastic Agents,
  • Nucleic Acid Conformation

  • Edition Notes

    Includes bibliographical references and index.

    StatementStephen Neidle
    Classifications
    LC ClassificationsRM666.N87 N45 2012
    The Physical Object
    Paginationxii, 196 p. :
    Number of Pages196
    ID Numbers
    Open LibraryOL25141066M
    ISBN 100123751381
    ISBN 109780123751386
    LC Control Number2011293620
    OCLC/WorldCa759821822

    Nucleic Acid Therapeutics is the leading journal in its field focusing on cutting-edge basic research, therapeutic applications, and drug development using nucleic acids or related compounds to alter gene expression. The Journal examines many new approaches for using nucleic acids as therapeutic agents or in modifying nucleic acids for therapeutic purposes including: oligonucleotides, gene. G-quadruplex is a special secondary structure of nucleic acids in guanine-rich sequences of genome. G-quadruplexes have been proved to be involved in the regulation of replication, DNA damage repair, and transcription and translation of oncogenes or other cancer-related genes. Therefore, targeting G-quadruplexes has become a novel promising anti-tumor by: 4.

    G-quadruplexes constitute a unique class of nucleic acid structures formed by G-rich oligonucleotides of DNA- or RNA-type. Depending on their chemical nature, loops length, and localization in the sequence or structure molecularity, G-quadruplexes are highly polymorphic structures showing various folding topologies. They may be formed in the human genome where they are believed to play a Cited by: 2. Review Therapeutic Applications Of Quadruplex Nucleic Acids English Edition Rop5zvj2 images. Or see: New Jersey Pendlerzug Kracht In Bahnhof Video or Oxalis Triangularis Skötsel. Enter.

      Complete, up-to-date coverage of the broad area of nucleic acid chemistry and biology. Assembling contributions from a collection of authors with expertise in all areas of nucleic acids, medicinal chemistry, and therapeutic applications, Medicinal Chemistry of Nucleic Acids presents a thorough overview of nucleic acid chemistry—a rapidly evolving and highly challenging discipline . G-Quadruplex Nucleic Acids: Methods and Protocols (1st ed. ) (Methods in Molecular Biology #) including therapeutic intervention and biomaterial application. The chapters in this book explore a wide range of vital and new experimental techniques used in the study of G-quadruplexes. Written in the highly successful Methods in.


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Therapeutic applications of quadruplex nucleic acids by Stephen Neidle Download PDF EPUB FB2

Therapeutic Applications of Quadruplex Nucleic Acids provides a single comprehensive survey that describes and assesses recent advances in quadruplex therapeutics and targeting strategies.

It also covers the underlying fundamentals of such topics as quadruplex structure, small-molecule recognition, biological roles of genomic quadruplexes, and quadruplex informatics. Therapeutic Applications of Quadruplex Nucleic Acids provides a single comprehensive survey that describes and assesses recent advances in quadruplex therapeutics and targeting strategies.

It also covers the underlying fundamentals of such topics as quadruplex structure, small-molecule recognition, biological roles of genomic quadruplexes, and quadruplex by: Therapeutic Applications of Quadruplex Nucleic Acids - Kindle edition by Neidle, Stephen. Download it once and read it on your Kindle device, PC, phones or tablets.

Use features like bookmarks, note taking and highlighting while reading Therapeutic Applications of Quadruplex Nucleic by: "Therapeutic applications of quadruplex nucleic acids provides a single comprehensive survey that describes and assesses recent advances in quadruplex therapeutics and targeting strategies.

It also covers the underlying fundamentals of such topics as quadruplex structure, small-molecule recognition, biological roles of genomic quadruplexes, and quadruplex informatics"--Page 4 of cover.

Therapeutic Applications of Quadruplex Nucleic Acids provides a single comprehensive survey that describes and assesses recent advances in quadruplex therapeutics and targeting strategies. It also covers the underlying fundamentals of such topics as quadruplex structure, small-molecule recognition, biological roles of genomic quadruplexes, and quadruplex : Elsevier Science.

Quadruplex Nucleic Acids as Therapeutic Therapeutic applications of quadruplex nucleic acids book will be a vital resource for researchers in biochemistry, molecular biology, chemistry, biotechnology, biophysics, medicine, translational science Author: Stephen Neidle.

Quadruplex Nucleic Acids as Therapeutic Targets will be a vital resource for researchers in biochemistry, molecular biology, chemistry, biotechnology, biophysics, medicine, translational science and pharmacology. Read Book Online Now ?book=BOI23T4Read Therapeutic Applications of Quadruplex Nucleic Acids Ebook Free.

About this book. About this book. This volume covers the structures, properties, and functions of G-quadruplexes in a wide range of biological disciplines, including therapeutic intervention and biomaterial application.

The chapters in this book explore a wide range of vital and new experimental techniques used in the study of G-quadruplexes. G-rich nucleic acids can form non-canonical G-quadruplex structures (G4s) in which four guanines fold in a planar arrangement through Hoogsteen hydrogen bonds.

Although many biochemical and structural studies have focused on DNA sequences containing successive, adjacent guanines that spontaneously fold into G4s, evidence for their in vivo Cited by: Calculation of Hydrodynamic Properties for G-Quadruplex Nucleic Acid Structures from in silico Bead Models, by Huy T.

Le, Robert Buscaglia, William L. Dean, Jonathan B. Chaires and John O. Trent.- Energetics of Ligand Binding to G-Quadruplexes, Concetta Giancola and Bruno Pagano   Perspectives on Chemistry and Therapeutic Applications of Locked Nucleic Acid (LNA) Harleen Kaur; Solution Structure of a Locked Nucleic Acid Modified Quadruplex: Introducing the V4 Folding Topology.

Angewandte ChemiePerspectives on Chemistry and Therapeutic Applications of Locked Nucleic Acid (LNA).Cited by: G-Quadruplex Nucleic Acids Methods and Protocols.

Editors (view affiliations) Danzhou Yang; Clement Lin; Book. including therapeutic intervention and biomaterial application. The chapters in this book explore a wide range of vital and new experimental techniques used in the study of G-quadruplexes.

The study of G-quadruplexes has emerged in recent years as an important focus of research in nucleic acids. This is now a rapidly growing area, not least because of its potential as a novel approach to cancer therapeutics, and there is much curren.

Therapeutic Applications of Quadruplex Nucleic Acids - The study of G-quadruplexes has emerged in recent years as an important focus of research in nucleic acids This is. Diagnostic and Therapeutic Applications of Exosomes in Cancer evaluates the potential of exosome content manipulation in the development of novel therapeutics.

In recent years, exosomes, the small vesicles produced by all cell types, have been identified as contributors to cancer growth and metastasis. [7][8][9][10][11][12][13] The functional significance of quadruplex nucleic acids has intensified the research on the development of G-quadruplex interactive compounds with potential : Stephen Neidle.

The application of click chemistry for targeting quadruplex nucleic acids. Chemical Communications55 (6), DOI: /C8CCA. Andres Garcia-Sampedro, Andrea Tabero, Ismahan Mahamed, Pilar Acedo.

Multimodal use of the porphyrin TMPyP: From cancer therapy to antimicrobial by: Read Therapeutic Applications of Quadruplex Nucleic Acids by Stephen Neidle for free with a 30 day free trial.

Read unlimited* books and audiobooks on the web, iPad, iPhone and Android. The study of G-quadruplexes has emerged in recent years as an important focus of research in nucleic acids. Quadruplex nucleic acids — helical four-stranded structures known to form from guanine-rich nucleic acid sequences through Hoogsteen-type hydrogen bonding — were once just laboratory by:.

The intriguing structural diversity in folded topologies available to guanine-rich nucleic acid repeat sequences have made four-stranded G-quadruplex structures the focus of both basic and applied research, from cancer biology and novel therapeutics through to nanoelectronics.

Distributed widely in the human Advances in DNA-based nanotechnologyCited by:   Quadruplex Nucleic Acids as Novel Therapeutic Targets. 1. J Med Chem. Jul 14;59(13) doi: /em.5b Epub Feb Quadruplex Nucleic Acids as Novel Therapeutic Targets.

Neidle S(1). Author information: (1)UCL School of Pharmacy, University College London, Brunswick Square, London WC1N 1AX, by: Product Type: Book Edition: 1 First Published: Hardcover: eBook: